李春艳

职称：教授

性别：女

职务：

办公电话：

移动电话：隐藏

家庭电话：

家庭住址：隐藏

电子邮箱：lichunyan79@sina.com

工作学习经历

主讲课程

分析化学、光谱分析、色谱分析

研究方向 

有机小分子荧光探针的设计合成，纳米荧光探针的构建，荧光探针在生化分析中的应用

主要学术成果 

承担项目（主持）

[1] 国家自然科学基金面上项目，糖类受体靶向性近红外荧光探针的构建及在炎症性肠病成像中的应用研究，2022-2025；

[2] 国家自然科学基金面上项目，基于缺氧诱导释放的近红外诊疗探针的构建及其初步生物医学应用研究，2018-2021；

[3] 国家自然科学基金青年项目，基于能量转移机理的蛋白激酶比率荧光分子探针的设计合成及生物医学应用，2011-2013；

[4] 湖南省自然科学基金项目面上项目，双模态成像探针的构建及在炎症性肠病早期诊断中的应用研究，2021-2023；

[5] 湖南省自然科学基金项目青年人才培养基金，定位线粒体的比率型三磷酸腺苷荧光探针的研究，2015-2017；

[6] 湖南省自然科学基金项目面上项目，能量转移型蛋白激酶荧光探针的研究，2011-2013；

[7] 中国博士后科学基金特别资助项目，定位线粒体的比率型荧光探针的研究，2015-2016；

[8] 中国博士后科学基金面上项目，能量转移型荧光探针的研究，2014-2016；

[9] 湖南省教育厅重点项目，缺氧诊疗荧光探针的研究，2019-2021；

[10] 湖南省教育厅优秀青年项目，用于三磷酸腺苷定位和检测的双功能比率荧光探针的构建及细胞成像研究，2016-2018。

近5年发表论文（通讯作者）

[1] Long-term imaging of Cys in cells and tumor mice by a solid-state fluorescence probe. Analytical Chemistry, 2023, 95, 17559-17567. (IF: 7.4)

[2] Tumor-targeting probe for dual-modal imaging of cysteine in vivo. Analytical Chemistry, 2023, 95, 12478-12486. (IF: 7.4)

[3] Near-infrared fluorescent nanoprobes for adenosine triphosphate guided imaging in cancer and fatty liver mice, Analytical Chemistry, 2023, 95, 2119-2127. (IF: 7.4)

[4] Dual key-activated NIR-I/II fluorescence probe for monitoring photodynamic and photothermal synergistic therapy efficacy. Advanced Healthcare Materials, 2023, 12, 2301230. (IF: 10.0)

[5] A novel near-infrared fluorescent probe for the imaging of viscosity in cells and tumor-bearing mice. Chemical Communications, 2023, 59, 5607-5610. (IF: 4.9)

[6] A tumor-targeting fluorescent probe for ratiometric imaging of pH and improving PDT/PTT synergistic therapy. Sensors and Actuators: B. Chemical, 2023, 393, 134287. (IF: 8.4)

[7] A near-infrared fluorescent probe for monitoring abnormal mitochondrial viscosity in cancer and fatty-liver mice model. Analytica Chimica Acta, 2023, 1242, 340813. (IF: 6.2)

[8] A dual-channel fluorescent nanoprobe for accurate cancer diagnosis by sequential detection of adenosine triphosphate and sulfur dioxide. Talanta, 2023, 265, 124815. (IF: 6.1)

[9] A near-infrared fluorescent probe for detecting hydrogen sulfide with high selectivity in cells and ulcerative colitis in mice. Analyst, 2023, 148, 5724-5730. (IF: 4.2)

[10] Recent advances in design strategies and imaging applications of fluorescent probes for ATP. Chemosensors, 2023, 11, 417. (IF: 3.108)

[11] Near-infrared fluorescent probe with large stokes shift for imaging of hydrogen sulfide in tumor-bearing mice, Analytical Chemistry, 2022, 94, 5514-5520. (IF: 7.4)

[12] A dual-channel fluorescent nanoprobe for sequential detection of ATP and peroxynitrite to accurately distinguish between normal cells and cancer cells, Analytical Chemistry, 2022, 94, 14257-14264. (IF: 7.4)

[13] ATP fluorescent nanoprobe based on ZIF-90 and near-infrared dyes for imaging in tumor mice, Sensors & Actuators: B. Chemical, 2022, 369, 132286. (IF: 8.4)

[14] ATP-responsive near-infrared fluorescent nanoparticles for synergistic chemotherapy and starvation therapy, Nanoscale, 2022, 14, 3808-3817. (IF: 6.7)

[15] A dual-response fluorescent probe for simultaneously monitoring polarity and ATP during autophagy, Journal of Materials Chemistry B, 2022, 10, 4285-4292. (IF: 7.0)

[16] A tumor-targeting near-infrared fluorescent probe for real-time imaging ATP in cancer cells and mice, Analytica Chimica Acta, 2022, 1206, 339798. (IF: 6.2)

[17] A HPQ-based far-red fluorescent probe for monitoring viscosity in mice model of acute inflammation, Analytica Chimica Acta, 2022, 1226, 340192. (IF: 6.2)

[18] A novel precipitating-fluorochrome-based fluorescent probe for monitoring carbon monoxide during drug-induced liver injury, Talanta, 2022, 243, 123398. (IF: 6.1)

[19] A nitrobenzoxadiazole-based near-infrared fluorescent probe for the specific imaging of H₂S in inflammatory and tumor mice, Analyst, 2022, 147, 2712-2717. (IF: 4.2)

[20] A tumor-targeting and polarity-specific near-infrared fluorescent probe for accurate cancer diagnosis in vivo, Dyes and Pigments, 2022, 206, 110612. (IF: 4.5) 

[21] Accurate fluorescence diagnosis of cancer based on sequential detection of hydrogen sulfide and pH, Analytical Chemistry, 2021, 93, 11826-11835. (IF: 7.4) 

[22] Monitoring the fluctuation of hydrogen peroxide in diabetes and its complications with a novel near-infrared fluorescent probe, Analytical Chemistry, 2021, 93, 3301-3307. (IF: 7.4) 

[23] Construction of NIR and ratiometric fluorescent probe for monitoring carbon monoxide under oxidative stress in zebrafish, Analytical Chemistry, 2021, 93, 2510-2518. (IF: 7.4) 

[24] NAD(P)H-triggered probe for dual-modal imaging during energy metabolism and novel strategy of enhanced photothermal therapy in tumor, Biomaterials, 2021, 271, 120736. (IF: 14.0) 

[25] A novel near-infrared theranostic probe for accurate cancer chemotherapy in vivo by a dual activation strategy, Chemical Communications, 2021, 57, 13768-13771. (IF: 4.9) 

[26] A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H⁺, Chemical Communications, 2021, 57, 4811-4814. (IF: 4.9) 

[27] Real-time imaging of alkaline phosphatase activity of diabetes in mice via a near-infrared fluorescent probe, Chemical Communications, 2021, 57, 480-483. (IF: 4.9) 

[28] A novel HPQ-based fluorescent probe for the visualization of carbon monoxide in zebrafish, Sensors and Actuators B: Chemical, 2021, 340, 129920. (IF: 8.4) 

[29] A near-infrared fluorescent probe with large Stokes shift for imaging Cys in tumor mice, Analytica Chimica Acta, 2021, 1171, 338655. (IF: 6.2)

[30] Novel near-infrared fluorescence probe with large Stokes shift for monitoring CCl₄-induced toxic hepatitis, Talanta, 2021, 223, 121720. (IF: 6.1) 

[31] ATP-responsive near-infrared fluorescence MOF nanoprobe for the controlled release of anticancer drug. Microchimica Acta, 2021, 188, 287. (IF: 5.7) 

[32] The construction of a near-infrared fluorescent probe with dual advantages for imaging carbon monoxide in cells and in vivo. Analyst, 2021, 146, 118-123. (IF: 4.2) 

[33] Novel strategy for validating the existence and mechanism of the “gut-liver axis” in vivo by a hypoxia-sensitive NIR fluorescent probe, Analytical Chemistry, 2020, 92, 4244-4250. (IF: 7.4) 

[34] Near-infrared fluorescence MOF nanoprobe for adenosine triphosphate-guided imaging in colitis, ACS Applied Materials & Interfaces, 2020, 12, 47840-47847. (IF: 9.5) 

[35] Near-infrared fluorescence probe with a large stokes shift for visualizing hydrogen peroxide in ulcerative colitis mice, Sensors and Actuators B: Chemical, 2020, 320, 128296. (IF: 8.4)

[36] A novel hepatocyte-targeting ratiometric fluorescent probe for imaging hydrogen peroxide in zebrafish, Sensors and Actuators B: Chemical, 2020, 313, 128054. (IF: 8.4)

[37] A facile pH near-infrared fluorescence probe for the diagnosis of cancer in vivo, Dyes and Pigments, 2020, 179, 108402. (IF: 4.5) 

[38] A near-infrared fluorescence probe with a large Stokes shift for detecting carbon monoxide in living cells and mice, Dyes and Pigments, 2020, 180, 108517. (IF: 4.5) 

[39] In-situ imaging of azoreductase activity in the acute and chronic ulcerative colitis mice by a near-infrared fluorescent probe. Analytical Chemistry, 2019, 91, 10901-10907. (IF: 7.4)

[40] Fluorescence-guided cancer diagnosis and surgery by a zero cross-talk ratiometric near-infrared γ-glutamyltranspeptidase fluorescent probe. Analytical Chemistry, 2019, 91, 1056-1063. (IF: 7.4)

[41] A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation. Chemical Communications, 2019, 55, 14307-14310. (IF: 4.9)

[42] A rhodamine-deoxylactam based fluorescent probe for fast and selective detection of nitric oxide in living cells. Talanta, 2019, 197, 436-443. (IF: 6.1)

[43] A ratiometric fluorescent probe for the detection of peroxynitrite with simple synthesis and large emission shift and its application in cells image. Dyes and Pigments, 2019, 161, 288-295. (IF: 4.5) 

近3年授权专利

[1] 基于噻吩-氧杂蒽染料的硫化氢荧光探针的制备和应用，专利号ZL2022107967759.

[2] 一种基于硅罗丹明的近红外MOF荧光探针的制备和应用，专利号ZL2022102869266.

[3] 基于异佛尔酮-肉桂醛的粘度荧光探针的制备和应用，专利号ZL2021108175659.

[4] 基于花菁染料的靶向性比率pH荧光探针的制备和应用，专利号ZL2022104956269.

[5] 李春艳，刘娟，一种半胱氨酸近红外荧光探针的制备和应用，专利号2020104384010.

[6] 基于花菁染料的靶向性半胱氨酸荧光探针的制备和应用，专利号ZL2022103209367. 

[7] 一种过氧化氢近红外荧光探针的制备和应用，专利号ZL2019108966253.

[8] 一种pH近红外荧光探针的制备和应用，专利号ZL2019110493775.

[9] 一种一氧化碳近红外荧光探针的制备和应用，专利号ZL2019110846175.

[10] 基于喹啉-氧杂蒽的碱性磷酸酶荧光探针的制备和应用，专利号ZL2020107090485.

[11] 一种检测一氧化碳的打开型荧光探针的制备和应用，专利号ZL2020104523723.

[12] 一种检测一氧化碳的固态荧光探针的制备和应用，专利号ZL2021107304883.

[13] 基于异佛尔酮-氧杂蒽的硫化氢荧光探针的制备和应用，专利号ZL2021102732199.

[14] 一种基于半花菁染料的缺氧荧光探针的制备和应用，专利号ZL2019104095554.

[15] 基于吡喃-香豆素的一氧化碳荧光探针的制备和应用，专利号ZL2019110087606.

[16]  一种过氧亚硝基比率型荧光探针的制备和应用，专利号ZL2019104742198.

[17] 基于脱氧罗丹明的一氧化氮荧光探针的制备和应用，专利号ZL201811120191X.

研究生培养

[1] 在读：王之卿（博士），钞静静（博士），李婷，陈思思，张会，胡玲，秦崇康，杨志超，宋倩，李莉，许小帆，杨志豪，陈丽缘，贺培德，邓伟群，刘嘉雨

[2] 已毕业：江文丽（博士，校长奖特等奖），王文新（博士，国家奖学金，校长奖），侯美家，闫灵，廖沁婷，付贵勤（国家奖学金），顾青松，陈骏涛，刘娟，夏雨桑，佘遵攀（湖南省优秀硕士学位论文），陈茜茜，赵仪婷，田杨（校长奖，湖南省优秀硕士学位论文），张烁，周东叶，欧阳娟（国家奖学金，校长奖特等奖，湖南省优秀硕士学位论文），李宋娇（国家奖学金），谢俊英（国家奖学金，校长奖），谭凯月，付雅俊，吴银双（国家奖学金），李丹，李芝，唐佳良（国家奖学金），卢曦，邹春香（国家奖学金），孔雪飞（校长奖），周雨（校长奖），徐芬（校长奖）

个人简介 

李春艳，教授，博士生导师，2008年博士毕业于湖南大学化学化工学院。2013年入选首届金沙9170登录线路青年拔尖人才计划，2017年入选金沙9170登录线路韶峰学者学术骨干。2019年入选中国化学会“中国青年化学家元素周期表”，并代言“汞”元素。2023年入选全球前2%顶尖科学家榜单。主要从事有机小分子探针设计合成、纳米荧光探针的构建和荧光探针在生化分析中的应用研究。主持国家自然科学基金面上项目/青年项目、中国博士后基金面上项目/特别资助项目、湖南省自然科学基金、湖南省教育厅重点项目/优秀青年项目等课题。近年来，以通讯作者在Analytical Chemistry、Chemical Communication、Advanced Healthcare Materials、Biomaterials、ACS Applied Materials & Interfaces等国际刊物发表论文82篇，论文被引4072次，有2篇入选SCI高被引论文。担任《化学试剂》编委和Journal of Analysis and Testing青年编委。获授权的发明专利26项，多项专利具有很好的应用价值，正在积极的推广中。获湖南省自然科学奖二等奖1项，排名第二。已培养研究生50人，毕业34人（其中博士2人），在读16人（其中博士2人），指导研究生多次获得研究生国家奖学金、湖南省优秀硕士学位论文、金沙9170登录线路“研究生校长奖”特等奖等荣誉。