欧阳娟

职称：助理研究员

性别：女

职务：专任教师

办公电话：隐藏

移动电话：隐藏

家庭电话：隐藏

家庭住址：隐藏

电子邮箱：oyj2023@xtu.edu.cn

工作学习经历

主讲课程

《分析化学》、《分析化学实验》

研究方向 

功能光学探针的设计、合成及应用

主要学术成果 

承担项目（主持）：

[1]金沙9170登录线路人才引进科研启动项目，靶向性多功能光学探针的构建及在自身免疫性疾病中的应用，2023-2029年；

[2]广东省自然科学基金面上项目，多功能超分子纳米体系的构建及在牙周病诊断和治疗中的应用，2024-2026年；

[3] 中国博士后科学基金第72批面上资助（二等），抗菌-抗炎症纳米诊疗体系的构建及其在牙周病中的应用，2023年；

[4] 湖南省研究生科研创新项目，靶向线粒体的三磷酸腺苷比率荧光探针的构建及细胞成像研究，2017-2019年。

发表学术论文：

[1] Juan Ouyang, Lihe Sun, Zhou Zeng, Cheng Zeng, Fang Zeng, Shuizhu Wu, Nanoaggregate probe for breast cancer metastasis through multispectral optoacoustic tomography and aggregation-induced NIR-I/II fluorescence imaging. Angewandte Chemie International Edition, 2020, 59, 10111-10121. (IF = 16.6)；

[2] Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu, Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging. Coordination Chemistry Reviews, 2022, 456, 214438. (IF = 20.6)

[3] Juan Ouyang, Lihe Sun, Jiayue Pan, Zhuo Zeng, Cheng Zeng, Fang Zeng, Mei Tian, Shuizhu Wu, A targeted nanosystem for detection of inflammatory diseases via fluorescent/optoacoustic imaging and therapy via modulating Nrf2/NF-κB pathways. Small, 2021, 17, 2102598. (IF = 13.3)

[4] Lihe Sun^#, Juan Ouyang^#, Fang Zeng, Shuizhu Wu, An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome. Biomaterials, 2022, 283, 121468. (共同一作，IF = 14.0)

[5] Lihe Sun^#, Juan Ouyang^#, Zhuo Zeng, Cheng Zeng, Yunqing Ma, Fang Zeng, Shuizhu Wu, Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways. Bioactive Materials, 2022, 10, 79-92. (共同一作，IF = 18.9)

[6] Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu, Rational design of stable heptamethine cyanines and development of a biomarker-activatable probe for detecting acute lung/kidney injuries via NIR-II fluorescence imaging. Analyst, 2022, 147, 410-416. (IF = 4.2)

[7] Lihe Sun^#, Juan Ouyang^#, Yunqing Ma, Zhuo Zeng, Cheng Zeng, Fang Zeng, Shuizhu Wu, An activatable probe with aggregation-induced emission for detecting and imaging herbal medicine induced liver injury with optoacoustic imaging and NIR-II fluorescence imaging. Advanced Healthcare Materials, 2021, 10, 2100867. (共同一作，IF = 10.0)

[8] Zhou Zeng^#, Juan Ouyang^#, Lihe Sun, Cheng Zeng, Fang Zeng, Shuizhu Wu, Activatable nanocomposite probe for preoperative location and intraoperative navigation for orthotopic hepatic tumor resection via MSOT and aggregation-induced near-IR-I/II fluorescence imaging. Analytical Chemistry, 2020, 92, 9257-9664. (共同一作，IF = 7.4)

[9] Juan Ou-Yang, Yongfei Li, Wen-Li Jiang, Shuang-Yan He, Hong-Wen Liu, Chun-Yan Li, Fluorescence-guided cancer diagnosis and surgery by a zero cross-talk ratiometric near-infrared γ‑glutamyltranspeptidase fluorescent probe. Analytical Chemistry, 2019, 91, 1056-1063. (IF = 7.4)

[10] Juan Ou-Yang, Yongfei Li, Ping Wu, Wen-Li Jiang, Hong-Wen Liu, Chun-Yan Li, Detecting and imaging of γ‑glutamytranspeptidase activity in serum, live cells, and pathological tissues with a high signal-stability probe by releasing a precipitating fluorochrome. ACS Sensors, 2018, 3, 1354-1361. (IF = 8.9)

[11] Juan Ou-Yang, Wen-Li Jiang, Kai-Yue Tan, Hong-Wen Liu, Song-Jiao Li, Juan Liu, Yongfei Li, Chun-Yan Li, Two-photon fluorescence probe for precisely detecting endogenous H₂S in lysosome by employing a dual lock system. Sensors and Actuators B: Chemical, 2018, 260, 264-273. (IF = 8.4)

[12] Juan Ou-Yang, Chun-Yan Li, Yongfei Li, Bin Yang, Song-Jiao Li, An infinite coordination polymer nanoparticles-based near-infrared fluorescent probe with high photostability for endogenous alkaline phosphatase in vivo. Sensors and Actuators B: Chemical, 2018, 255, 3355-3363. (IF = 8.4)

[13] Juan Ou-Yang, Chun-Yan Li, Yongfei Li, Junjie Fei, Fen Xu, Song-Jiao Li, Shi-Xin Nie, A rhodamine-based fluorescent probe with high water solubility and its application in the detection of glutathione with unique specificity. Sensors and Actuators B: Chemical, 2017, 240, 1165-1173. (IF = 8.4)

[14] Zhi Li^#, Juan Ou-Yang^#, Ya-Jun Fu, Chun-Yan Li, Yongfei Li, Song-Jiao Li, A borondipyrrolemethene-based turn-on fluorescent probe for silver ion with high sensitivity and selectivity and its application in water samples and living cells. Tetrahedron Letters, 2017, 58, 3536-3540. (共同一作，IF = 1.8)

授权专利：

[1] 基于罗丹明的GSH水溶性荧光探针的制备方法和应用，专利号ZL201610821181.3；

个人简介 

欧阳娟，女，湖南株洲人，中共党员。2015年本科毕业于金沙9170登录线路化工学院；2018年硕士毕业于金沙9170登录线路，师从李春艳教授；2021年博士毕业于华南理工大学材料科学与工程学院，师从吴水珠教授；随后留校继续博士后研究，合作导师为曾钫教授和吴水珠教授。2023年11月加入金沙9170登录线路李春艳教授团队，硕士研究生导师，主要从事分子光学探针设计合成、多功能纳米诊疗体系的构建及其传感/检测/成像、诊断与治疗等方面的应用研究。相关成果在Coordination Chemistry Reviews, Angewandte Chemie International Edition, Small, Biomaterials, Bioactive Materials, Analytical Chemistry等国际著名期刊上发表论文26篇（其中一作含共同一作论文14篇），申请国家授权发明专利1项，先后主持湖南省研究生科研创新项目、中国博士后科学基金面上资助项目、广东省自然科学基金面上项目和金沙9170登录线路人才引进科研启动项目等科研项目4项，并参与国家自然科学基金面上项目数项。曾获得“湖南省优秀硕士学位论文”、“博士研究生国家奖学金”、“华南理工大学校长奖学金”、“湘潭市自然科学优秀学术论文一等奖”、“金沙9170登录线路特等校长奖学金”和“硕士研究生国家奖学金”等荣誉。

学术主页：https://www.researchgate.net/profile/Juan-Ouyang-4/publications 

欢迎有志于分析化学研究的优秀学生报考！